COVID-19 Vaccine Provider Guidance

Vaccination providers are fundamental to COVID-19 vaccination plans. This webpage is a key resource for providing South Carolina's vaccination providers with the most current information available.

On October 16, 2020, South Carolina submitted its COVID-19 Vaccination Plan to the U.S. Department of Health and Human Services. The overarching goal of this vaccination plan is the equitable distribution of the vaccine across the state, based on the most current federal guidance and recommendations. Read South Carolina's plan, updated December 7, 2020, by clicking below.

Guidance for COVID-19 Allocation

COVID-19 Vaccination Provider Enrollment

To receive and administer the coronavirus vaccine and supplies, providers have to enroll in a federal vaccine distribution program, coordinated through the state's immunization program (unless they are part of a national chain that registered directly with the CDC). The federal government will procure and distribute the vaccine at no cost to enrolled providers. 

Enrollment Process Demonstration Videos

Frequently Asked Questions (FAQs) for Vaccination Providers Enrollment

We will continue to update this information as often as possible to provide the most factual and current information possible for South Carolinians. Click here to view frequently asked questions.

SIMON for Vaccine Providers

South Carolina's Statewide Immunization Online Network (SIMON) launched September 13, 2020 as a new immunization information system that will help the agency and immunization providers ensure access and availability of essential immunizations to help keep South Carolinians healthy. Access SIMON

Inventory Reporting Requirement for Enrolled COVID-19 Providers

The COVID-19 Vaccination Program Provider Agreement requires providers to report vaccine supply information as directed by CDC. Locations receiving COVID-19 vaccine should report supply information daily (Mon-Sun) to VaccineFinder using the online COVID Locating Health Provider Portal. Vaccination providers can report manually via the secure COVID Locating Health Provider Portal, or via an automated secure data transfer directly to the COVID Locating Health Platform.
Questions? Please email

Additional helpful resources and information:

Vaccine Administration Management Systems (VAMS)

VAMS is a secure, web-based tool built to help SC DHEC, vaccination clinics, organizations/employers, and vaccine recipients manage COVID-19 vaccination efforts during phase 1 (limited vaccine supply). It supports operations and data collection and tracking to meet CDC, Operation Warp Speed (OWS), and South Carolina DHEC COVID-19 vaccination requirements. DHEC’s Phase 1 providers will register their clinic information in VAMS, SC employers and organizations with priority populations (TBD) will register their phase 1 populations in VAMS, and phase 1 populations will schedule vaccination services at phase 1 clinic locations available in VAMS. Activated providers will receive detailed instructions related to VAMS Onboarding in their activation notification email.


Training Videos:

Questions? Please email

COVID-19 Vaccine Provider Training and Information Resources

CDC has developed a robust resource portfolio of COVID-19 vaccination resources for vaccine providers. Follow this link to view resources on patient education materials, COVID-19 vaccine training modules, and COVID-19 vaccine storage and handling.



COVID-19 Vaccine Provider Statewide