Multisystem Inflammatory Syndrome in Children (MIS-C)

Multisystem Inflammatory Syndrome in Children (MIS-C) occurs in children. It is a rare condition that can cause swelling of different organs, including the heart, lungs, liver, kidney, brain, eyes, stomach and intestines, and skin. While we do not know the exact cause of MIS-C, many children with the condition had COVID-19 or had been around someone with COVID-19.

Typically, the symptoms of MIS-C begin two to three weeks after COVID-19 infection. However, some children may not have symptoms when they have the COVID-19 virus and may not know they had been infected.

Symptoms of MIS-C generally start mildly and may include fever, stomach pain or diarrhea, vomiting, rash, and neck pain among others. In rare instances, these symptoms may become worse and require immediate care. Parents may find additional information on the CDC website and the CDC provides an infographic and overview of early cases of MIS-C in children across the country here. 

Healthcare providers may find additional information on the CDC website and on the DHEC website.

Please note that MIS-C is a reportable condition to DHEC (urgently reportable by phone within 24 hours to the regional health department).

On July 12, 2020, South Carolina announced its first confirmed cases of MIS-C associated with COVID-19.

Note: Cases by region will be updated on Friday afternoons once new cases are reported to DHEC.

COVID-19 MIS-C Map 12.4.2020



COVID-19 COVID-19 Resources Statewide