The South Carolina Maternal Mortality and Morbidity Review Committee (SCMMRC) first convened in 2016. The committee has 19 members, meets quarterly, and reviews all pregnancy-associated deaths. The mission of the SCMMMRC is to identify pregnancy-associated deaths (deaths during or within a year of pregnancy), review those caused by pregnancy complications and other selected deaths, and identify problems contributing to these deaths and interventions that may reduce these deaths. The goals of the committee’s reviews and associated maternal mortality work are to: determine the annual number of maternal deaths related to pregnancy (pregnancy-related mortality); identify trends and risk factors among pregnancy-related deaths in South Carolina; and develop actionable strategies for prevention and intervention.