While the 2022 Mpox outbreak has been declared over and the declared public health emergency has ended, low-level transmission of mpox is still occurring in the U.S.

Mpox transmission may still occur within South Carolina.

Providers should continue to test patients with clinical symptoms suggestive of mpox and offer or recommend mpox vaccination as part of routine STD care.

In addition, DHEC strongly recommends that people receive both doses of the mpox vaccination prior to activities that could lead to high-risk contact. There is some protection after the first dose, but the best protection occurs two weeks after the second dose. Jynneos vaccine continues to be made available through DHEC and selected provider clinics that routinely provide STD and HIV clinical services to those most at risk of exposure. You may search for options near you on the mpox vaccine provider map.

Educational Materials

The public, community partners, healthcare providers and others can share these materials to help increase awareness of and reduce exposure to mpox in South Carolina.

What Everyone Needs to Know

These materials provide information about what mpox is, its symptoms, and what you can do.

What You Need to Know About Mpox

Mpox is a rare but potentially serious viral illness that typically begins with flu-like symptoms and swelling of the lymph nodes and progresses to a rash on the face and body. Most infections last two to four weeks. Mpox, is a reportable condition in South Carolina as a novel infectious agent.

Mpox spreads between people primarily through direct contact with infectious sores, scabs, or bodily fluids. Mpox can spread during intimate contact between people, including sex, kissing, hugging, or talking closely; and touching fabrics and objects that were used by a person with mpox, such as bedding and towels. It can also be spread through coughing or saliva from a person with mpox.

  • Painful skin rash
  • Fever
  • Headache
  • Muscle aches
  • Swollen lymph nodes

Symptoms usually appear 7–14 days after exposure.

CDC Monkeypox Visuals

If you are concerned that you may have mpox or have had prolonged close contact with someone who has received a mpox diagnosis, please talk to your usual health care provider or if you do not have one, call your local health department or an Urgent Care.

At this time, the risk to the general public is low. Currently, the vast majority of cases are occurring among gay and bisexual men. However, anyone who has prolonged, skin-to-skin contact with someone who has mpox is at risk of being infected.

Key Information for Clinical Providers

Aug. 3, 2022: Dr. Linda Bell provides mpox information to our state's healthcare providers
  • If you suspect mpox in a patient, after your evaluation please report it to your DHEC regional epidemiology team. DHEC may initiate contact tracing pending laboratory results for highly probably cases and provide additional guidance.
  • Testing for mpox is available through commercial laboratories or the Public Health Laboratory. PHL testing requires pre-approval but has faster turnaround time. See HAN: Updated Guidance for Monkeypox Virus (MPOV) Evaluation (7-06-2022).
  • For individuals with severe cases of mpox, DHEC has pre-positioned TPOXX antiviral treatment across the state.  Please consult the DHEC Medical Consultant  covering your region to obtain TPOXX for a patient.   Do not call CDC directly.


Allendale, Bamberg, Beaufort,
Berkeley, Calhoun, Charleston,
Colleton, Dorchester, Hampton,
Jasper, Orangeburg

4050 Bridge View Drive, Suite 600
N. Charleston, SC 29405

Office: (843) 441-1091
Fax: (843) 953-0051
Nights/Weekends: (843) 441-1091


Aiken, Barnwell, Chester,
Edgefield, Fairfield, Lancaster,
Lexington, Kershaw, Newberry,
Richland, Saluda, York

2000 Hampton Street
Columbia, SC 29204

Office: (888) 801-1046
Fax: (803) 576-2993
Nights/Weekends: (888) 801-1046

Pee Dee

Clarendon, Chesterfield,
Darlington, Dillon, Florence,
Georgetown, Horry, Lee, Marion,
Marlboro, Sumter, Williamsburg

1931 Industrial Park Road
Conway, SC 29526

Office: (843) 915-8886
Fax: (843) 915-6506
Nights/Weekends: (843) 409-0695


Abbeville, Anderson, Cherokee,
Greenville, Greenwood, Laurens,
McCormick, Oconee, Pickens,
Spartanburg, Union

352 Halton Road
Greenville, SC 29607

Office: (864) 372-3133
Fax: (864) 282-4373
Nights/Weekends: (864) 423-6648


Monkeypox (MPX) Statewide