COVID-19 Vaccine Provider Guidance

Vaccine providers are fundamental to the successful rollout of the state's COVID-19 vaccination plan. This webpage is a key resource for keeping South Carolina's vaccine providers updated with the most current information available.

On Aug. 23, 2021, the FDA issued full approval of the Pfizer vaccine for those 16 and older. This full approval further indicates how safe and effective the vaccines are.

As of May 12, 2021, all South Carolinians age 12 and older can receive their COVID-19 vaccine. All three vaccines—Pfizer, Moderna and Janssen—are available to those aged 18 and older, and Pfizer is the only vaccine available to those 12 and older. 

In South Carolina, individuals 16 and older are able to consent to vaccination without parental permission. However, consent is required by a parent or legal guardian for children ages 12-15 before they can receive their Pfizer vaccine. All vaccine providers have their own unique immunization consent forms. Those 12 and older do not need to be accompanied by a parent or guardian at the time they receive their shot.

COVID-19 Vaccine Provider Weekly Updates

Guidance for COVID-19 Allocation

COVID-19 Vaccination Provider Enrollment

To receive and administer the coronavirus vaccine and supplies, providers have to enroll in a federal vaccine distribution program, coordinated through the state's immunization program (unless they are part of a national chain that registered directly with the CDC). The federal government will procure and distribute the vaccine at no cost to enrolled providers. 

Enrollment Process Demonstration Videos

Frequently Asked Questions (FAQs) for Vaccination Providers Enrollment

We will continue to update this information as often as possible to provide the most factual and current information possible for South Carolinians. Click here to view frequently asked questions.

Frequently Asked Questions (FAQs) for Vaccination Reimbursement

We will continue to update this information as often as possible to provide the most factual and current information possible for South Carolinians. Click here to view frequently asked questions.

SIMON for Vaccine Providers

South Carolina's Statewide Immunization Online Network (SIMON) launched September 13, 2020 as a new immunization information system that will help the agency and immunization providers ensure access and availability of essential immunizations to help keep South Carolinians healthy. Access SIMON

Inventory Reporting Requirement for Enrolled COVID-19 Providers

The COVID-19 Vaccination Program Provider Agreement requires providers to report vaccine supply information as directed by CDC. Locations receiving COVID-19 vaccine should report supply information daily (Mon-Sun) to VaccineFinder using the online COVID Locating Health Provider Portal. Vaccination providers can report manually via the secure COVID Locating Health Provider Portal, or via an automated secure data transfer directly to the COVID Locating Health Platform.
Questions? Please email

Additional helpful resources and information:

Vaccine Administration Management Systems (VAMS)

VAMS is a secure, web-based tool built to help SC DHEC, vaccination clinics, organizations/employers, and vaccine recipients manage COVID-19 vaccination efforts during phase 1 (limited vaccine supply). It supports operations and data collection and tracking to meet CDC, Operation Warp Speed (OWS), and South Carolina DHEC COVID-19 vaccination requirements. DHEC’s Phase 1 providers will register their clinic information in VAMS, SC employers and organizations with priority populations (TBD) will register their phase 1 populations in VAMS, and phase 1 populations will schedule vaccination services at phase 1 clinic locations available in VAMS. Activated providers will receive detailed instructions related to VAMS Onboarding in their activation notification email.


VAMS Readiness Checklists

Standard & Mobile Clinics

Third Party Clinics

Inventory Manager

Organization Coordinator


Questions? Please email

COVID-19 Vaccine Provider Training and Information Resources

CDC has developed a robust resource portfolio of COVID-19 vaccination resources for vaccine providers. Follow this link to view resources on patient education materials, COVID-19 vaccine training modules, and COVID-19 vaccine storage and handling.

Reporting Temperature Excursions COVID-19 Vaccines


View Archived Vaccine Provider Webinars


COVID-19 Provider Updates COVID-19 Vaccine Provider Statewide